Chromatin remodeling, BRCA1, SAHF and cellular senescence
نویسندگان
چکیده
منابع مشابه
Chromatin remodeling, BRCA1, SAHF and cellular senescence
Cellular senescence is a state of stable cell growth arrest. Activation of oncogenes in primary mammalian cells typically triggers cellular senescence. Oncogeneinduced senescence is an important tumor suppression mechanism, driving stable growth arrest of cancer progenitor cells harboring the initial oncogenic hit. Chromatin in the nuclei of senescent human cells is often reorganized to form sp...
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Cellular senescence has been implicated in tumor suppression, development, and aging and is accompanied by large-scale chromatin rearrangements, forming senescence-associated heterochromatic foci (SAHF). However, how the chromatin is reorganized during SAHF formation is poorly understood. Furthermore, heterochromatin formation in senescence appears to contrast with loss of heterochromatin in Hu...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.24986